Triptan Migraine Medicine – Triptan Side Effects
This content focuses on the topics below:
–Triptan Migraine Medicine
–Antidepressant Usage With Triptan Drug
-Triptan Medication For Migraine
-When to Take Triptans
-Triptan Side Effects
-Triptans And Calcitonin Gene-Related Peptide Receptor Antagonists
Triptans are a class of drugs known as serotonin receptor agonists. They were specifically designed as migraine therapy. Also they are the most commonly prescribe migraine medication today. Serotonin is a neurotransmitter that helps to regulate mood, appetite, sleep, and other brain functions. Triptans work by inhibiting the transmission of signals in certain nerve centers of the brainstem. By that way they seem to be able to terminate or reduce the complicated cascade of inflammation and vascular changes going on in the head that are associated with migraine head pain and migraine-related nausea, vomiting, and photophobia (sensitivity to light).
Antidepressant Usage With Triptan Drug
If you take antidepressants, talk to your doctor before taking a triptan drug. Selective serotonin reuptake inhibitors (SSRI) and selective serotonin/norepinephrine reuptake inhibitors (SNRI) are antidepressants that interact with triptans, and a life-threatening condition called serotonin syndrome can occur, though rarely, in patients taking both drugs.
The triptans include sumatriptan succinate (Imitrex), zolmitriptan (Zomig), eletriptan hydrobromide (Relpax), naratriptan hydrochloride (Amerge, Naramig), rizatriptan (Maxalt), frovatriptan succinate (Frova), and almotriptan malate (Axert). These drugs are available in various formulations, including oral drugs, nasal sprays, and injections (depending on the type of triptan). Doctors frequently prescribe the injectable form for those migraineurs who experience severe vomiting during a migraine attack.
Triptan Medication For Migraine – When to Take Triptans
Triptan drugs work best when you take them as soon as a migraine attack begins. Taking a triptan early also reduces side effects and decreases the chance of migraine recurring in the next twenty-four hours. Studies show that on average, triptans abort up to 8o percent of migraine headaches within two hours. Triptans can sometimes be used as a preventative, or prophylactic medication, particularly in the case of menstrual migraine. Chapter 8 has more details on triptans as prophylactics.
Triptan Side Effects
People who take an SSRI, SNRI, or monoamine oxidase (MAO) inhibitor should not take triptans without discussing risks carefully with their doctor, as these combinations can rarely cause serious and even life-threatening interactions. For example, you should not use Triptans with ergot derivatives (see previous section). Triptans can also cause some mild side effects including:
-Flushing of the skin
-Tingling of the skin
-Tightness in the chest or throat
-Drowsiness or fatigue
-Burning at injection site (for injectable sumatriptan)
Because of triptans can constrict blood vessels, People who have a history of heart attack should not take triptans . These drugs are not approved for use in pregnant women or in children under age eighteen, although they are sometimes prescribed for adolescents on an “off-label” basis when other treatment methods fail.
Triptans And Calcitonin Gene-Related Peptide Receptor Antagonists
Oral Calcitonin Gene-Related Peptide (CGRP) receptor antagonists are the newest class of migraine drugs under development. These drugs work by blocking the CGRP neurotransmitter, a pain-related brain chemical that is elevated during a migraine attack. Trials have shown that these drugs are similar in efficacy to triptans and may have fewer side effects.
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