Off-Label Drug Use?
What is off-label drug use? When a doctor prescribes a drug for a use that has not been approved by the U.S. Food and Drug Administration in the drug’s official labeling, it is called “off-label” use, which may be appropriate when it is backed by published medical literature or recommended by medical organizations or other government health agencies.
To Prevent Drug Dependence
To prevent drug dependence and rebound headache, opioid analgesics should be used no more frequently than two days a week. Overuse of opioids causes a patient to become physically dependent on the drug, and increasingly tolerant of doses, which have to be raised to achieve similar efficacy. When opioid use is stopped abruptly in someone who has become dependant on the drug, not only do headaches recur with increased severity but also symptoms of withdrawal can occur, including sweating, abdominal pain and nausea, vomiting, sweating, and diarrhea.
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